Abstract Search

ey0019.15-18 | Basic Science and Genetics | ESPEYB19

15.18. Life histories of myeloproliferative neoplasms inferred from phylogenies

N Williams , J Lee , E Mitchell , L Moore , EJ Baxter , J Hewinson , KJ Dawson , A Menzies , AL Godfrey , AR Green , PJ Campbell , J Nangalia

Nature. 2022;602(7895):162-8. doi: 10.1038/s41586-021-04312-6.PubMed ID: 35058638Brief summary: This study performed whole-genome sequencing (WGS) of 1013 clonal haematopoietic cell colonies from 12 adult patients aged 2081 years with myeloproliferative neoplasms, a form of blood cancer. They identified 580 133 somatic mutations and used these to reconstruct haematopoietic clonal his...

0 shares

ey0018.11-10 | Mechanism of the year | ESPEYB18

11.10. Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity

JR Brestoff , CB Wilen , JR Moley , Y Li , W Zou , NP Malvin , MN Rowen , BT Saunders , H Ma , MR Mack , BL Hykes , DR Balce , A Orvedahl , JW Williams , N Rohatgi , X Wang , MR McAllaster , SA Handley , BS Kim , JG Doench , BH Zinselmeyer , MS Diamond , HW Virgin , AE Gelman , SL Teitelbaum

Cell Metab 2021;33(2): 270–282.e8. doi: https://doi.org/10.1016/j.cmet.2020.11.008Brestoff et al. show, for the first time, that mitochondria are transferred from adipocytes to macrophages and that this event has an impact on systemic metabolic homeostasis.Within the last years, it has been demonstrated that cells are able to communicate with each other by the exchange of organell...

0 shares

ESPE Yearbook of Paediatric Endocrinology

15.18. Life histories of myeloproliferative neoplasms inferred from phylogenies

11.10. Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity

BiosciAbstracts